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Characterization of the tRNA ligases of pathogenic fungi Aspergillus fumigatus and Coccidioides immitis
Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that repairs RNA breaks with 2′,3′-cyclic-PO(4) and 5′-OH ends. Trl1 is composed of C-terminal cyclic phosphodiesterase and central polynucleotide kinase domains that heal the broken ends to generate the 3′-OH, 2′-PO(4), and 5′-PO(4) term...
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| Udgivet i: | RNA |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5029449/ https://ncbi.nlm.nih.gov/pubmed/27492257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.057455.116 |
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