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The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair

T4 RNA ligase 1 (Rnl1) is a tRNA repair enzyme that thwarts a tRNA-damaging host response to virus infection. The 374-aa Rnl1 protein consists of an N-terminal nucleotidyltransferase domain fused to a unique C-terminal domain composed of 10 α helices. We exploited an in vitro tRNA splicing system to...

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Detalhes bibliográficos
Main Authors: Wang, Li Kai, Nandakumar, Jayakrishnan, Schwer, Beate, Shuman, Stewart
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924901/
https://ncbi.nlm.nih.gov/pubmed/17585047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.591807
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