Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases

The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant transformation of iPSC derivatives has not been clearly defined due to insufficient analysis of histology and phenotype...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Sugai, Keiko, Fukuzawa, Ryuji, Shofuda, Tomoko, Fukusumi, Hayato, Kawabata, Soya, Nishiyama, Yuichiro, Higuchi, Yuichiro, Kawai, Kenji, Isoda, Miho, Kanematsu, Daisuke, Hashimoto-Tamaoki, Tomoko, Kohyama, Jun, Iwanami, Akio, Suemizu, Hiroshi, Ikeda, Eiji, Matsumoto, Morio, Kanemura, Yonehiro, Nakamura, Masaya, Okano, Hideyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027634/
https://ncbi.nlm.nih.gov/pubmed/27642008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0265-8
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