Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury

Neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) are considered to be a promising cell source for cell-based interventions that target CNS disorders. We previously reported that transplanting certain hiPSC-NS/PCs in the spinal cord results in tumor-lik...

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Udgivet i:Stem Cell Reports
Main Authors: Okubo, Toshiki, Iwanami, Akio, Kohyama, Jun, Itakura, Go, Kawabata, Soya, Nishiyama, Yuichiro, Sugai, Keiko, Ozaki, Masahiro, Iida, Tsuyoshi, Matsubayashi, Kohei, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063571/
https://ncbi.nlm.nih.gov/pubmed/27666789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.08.015
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