Human Genomic Safe Harbors and the Suicide Gene‐Based Safeguard System for iPSC‐Based Cell Therapy

The use of human induced pluripotent stem cells (hiPSCs) and recent advances in cell engineering have opened new prospects for cell‐based therapy. However, there are concerns that must be addressed prior to their broad clinical applications and a major concern is tumorigenicity. Suicide gene approac...

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Bibliografski detalji
Izdano u:Stem Cells Transl Med
Glavni autori: Kimura, Yasuyoshi, Shofuda, Tomoko, Higuchi, Yuichiro, Nagamori, Ippei, Oda, Masaaki, Nakamori, Masayuki, Onodera, Masafumi, Kanematsu, Daisuke, Yamamoto, Atsuyo, Katsuma, Asako, Suemizu, Hiroshi, Nakano, Toru, Kanemura, Yonehiro, Mochizuki, Hideki
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2019
Teme:
Pluripotent Stem Cells
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591650/
https://ncbi.nlm.nih.gov/pubmed/30887735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.18-0039
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