Human Genomic Safe Harbors and the Suicide Gene‐Based Safeguard System for iPSC‐Based Cell Therapy

The use of human induced pluripotent stem cells (hiPSCs) and recent advances in cell engineering have opened new prospects for cell‐based therapy. However, there are concerns that must be addressed prior to their broad clinical applications and a major concern is tumorigenicity. Suicide gene approac...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Kimura, Yasuyoshi, Shofuda, Tomoko, Higuchi, Yuichiro, Nagamori, Ippei, Oda, Masaaki, Nakamori, Masayuki, Onodera, Masafumi, Kanematsu, Daisuke, Yamamoto, Atsuyo, Katsuma, Asako, Suemizu, Hiroshi, Nakano, Toru, Kanemura, Yonehiro, Mochizuki, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591650/
https://ncbi.nlm.nih.gov/pubmed/30887735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.18-0039
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