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The phosphatase calcineurin regulates pathological TDP-43 phosphorylation

Detergent insoluble inclusions of TDP-43 protein are hallmarks of the neuropathology in over 90% of amyotrophic lateral sclerosis (ALS) cases and approximately half of frontotemporal dementia (FTLD-TDP) cases. In TDP-43 proteinopathy disorders, lesions containing aggregated TDP-43 protein are extens...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol
Hoofdauteurs: Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Currey, Heather N., Taylor, Laura M., Wheeler, Jeanna M., Oblak, Adrian L., Ghetti, Bernardino, Montine, Thomas J., Keene, C. Dirk, Raskind, Murray A., Bird, Thomas D., Kraemer, Brian C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026939/
https://ncbi.nlm.nih.gov/pubmed/27473149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1600-y
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