RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus

Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and lung epithelial cells. Replicating IAV drives assembly of a RIPK3-containing complex that includes the kinase R...

詳細記述

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書誌詳細
出版年:Cell Host Microbe
主要な著者: Nogusa, Shoko, Thapa, Roshan J., Dillon, Christopher P., Liedmann, Swantje, Oguin, Thomas H., Ingram, Justin P., Rodriguez, Diego A., Kosoff, Rachelle, Sharma, Shalini, Sturm, Oliver, Verbist, Katherine, Gough, Peter J., Bertin, John, Hartmann, Boris M., Sealfon, Stuart C., Kaiser, William J., Mocarski, Edward S., López, Carolina B., Thomas, Paul G., Oberst, Andrew, Green, Douglas R., Balachandran, Siddharth
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026823/
https://ncbi.nlm.nih.gov/pubmed/27321907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.05.011
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