RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus

Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and in vivo. We report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and lung epithelial cells. Replicating IAV drives assembly of a RIPK3-containing complex that includes the kinase R...

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Publicado no:Cell Host Microbe
Main Authors: Nogusa, Shoko, Thapa, Roshan J., Dillon, Christopher P., Liedmann, Swantje, Oguin, Thomas H., Ingram, Justin P., Rodriguez, Diego A., Kosoff, Rachelle, Sharma, Shalini, Sturm, Oliver, Verbist, Katherine, Gough, Peter J., Bertin, John, Hartmann, Boris M., Sealfon, Stuart C., Kaiser, William J., Mocarski, Edward S., López, Carolina B., Thomas, Paul G., Oberst, Andrew, Green, Douglas R., Balachandran, Siddharth
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026823/
https://ncbi.nlm.nih.gov/pubmed/27321907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.05.011
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