Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines

Activating mutations of the NRAS (neuroblastoma rat sarcoma viral oncogene) protein kinase, present in many cancers, induce a constitutive activation of both the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway and the PI(3)K-AKT-mTOR, pathway. This in turn regulat...

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Gepubliceerd in:Cell Cycle
Hoofdauteurs: Malka-Mahieu, Hélène, Girault, Isabelle, Rubington, Margot, Leriche, Melissa, Welsch, Caroline, Kamsu-Kom, Nyam, Zhao, Qian, Desaubry, Laurent, Vagner, Stéphan, Robert, Caroline
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026796/
https://ncbi.nlm.nih.gov/pubmed/27533468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1208862
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