Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22

Emerging evidences have shown that GSK3β plays oncogenic roles in multiple tumor types; however, the underlying mechanisms remain largely unknown. Herein, we show that nuclear GSK3β is responsible for the accumulation of the histone demethylase KDM1A and critically regulates histone H3K4 methylation...

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Библиографические подробности
Опубликовано в: :Nat Cell Biol
Главные авторы: Zhou, Aidong, Lin, Kangyu, Zhang, Sicong, Chen, Yaohui, Zhang, Nu, Xue, Jianfei, Wang, Zhongyong, Aldape, Kenneth D., Xie, Keping, Woodgett, James R., Huang, Suyun
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026327/
https://ncbi.nlm.nih.gov/pubmed/27501329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3396
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