Tumour suppressor TRIM33 targets nuclear β-catenin degradation

Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers but the fate of nuclear β-catenin is unknown. Here we demonstrate that tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin prote...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Xue, Jianfei, Chen, Yaohui, Wu, Yamei, Wang, Zhongyong, Zhou, Aidong, Zhang, Sicong, Lin, Kangyu, Aldape, Kenneth, Majumder, Sadhan, Lu, Zhimin, Huang, Suyun
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315364/
https://ncbi.nlm.nih.gov/pubmed/25639486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7156
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