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Tumour suppressor TRIM33 targets nuclear β-catenin degradation
Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers but the fate of nuclear β-catenin is unknown. Here we demonstrate that tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin prote...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4315364/ https://ncbi.nlm.nih.gov/pubmed/25639486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7156 |
| Oznake: |
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