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Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart

Ceramide accumulation is known to accompany acute myocardial ischemia, but its role in the pathogenesis of ischemic heart disease is unclear. In this study, we aimed to determine how ceramides accumulate in the ischemic heart and to determine if cardiac function following ischemia can be improved by...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Klevstig, M, Ståhlman, M, Lundqvist, A, Scharin Täng, M, Fogelstrand, P, Adiels, M, Andersson, L, Kolesnick, R, Jeppsson, A, Borén, J, Levin, MC
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026316/
https://ncbi.nlm.nih.gov/pubmed/26930027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.02.019
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