Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

BACKGROUND: Increased pulmonary ceramide levels are suggested to play a causative role in lung diseases including COPD. Neutral sphingomyelinase-2 (nSMase-2) and acid SMase (aSMase), which hydrolyze sphingomyelin to produce ceramide, are activated by a range of cellular stresses, including inflammat...

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Detalhes bibliográficos
Publicado no:Int J Chron Obstruct Pulmon Dis
Main Authors: Lea, Simon R, Metcalfe, Hannah J, Plumb, Jonathan, Beerli, Christian, Poll, Chris, Singh, Dave, Abbott-Banner, Katharine H
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019168/
https://ncbi.nlm.nih.gov/pubmed/27660431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S95578
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