Increased Expression of the Very Low-Density Lipoprotein Receptor Mediates Lipid Accumulation in Clear-Cell Renal Cell Carcinoma

Clear-cell renal cell carcinoma (RCC) is, in most cases, caused by loss of function of the tumor suppressor gene von Hippel–Lindau, resulting in constitutive activation of hypoxia-inducible factor (HIF)-1α and expression of hypoxia-induced genes in normoxic conditions. Clear-cell RCC cells are chara...

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Detalhes bibliográficos
Main Authors: Sundelin, Jeanna Perman, Ståhlman, Marcus, Lundqvist, Annika, Levin, Max, Parini, Paolo, Johansson, Martin E., Borén, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501495/
https://ncbi.nlm.nih.gov/pubmed/23185271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048694
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