Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart

Myocardial dysfunction is commonly associated with accumulation of cardiac lipid droplets (LDs). Perilipin 2 (Plin2) is a LD protein that is involved in LD formation, stability and trafficking events within the cell. Even though Plin2 is highly expressed in the heart, little is known about its role...

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Vydáno v:Sci Rep
Hlavní autoři: Mardani, Ismena, Tomas Dalen, Knut, Drevinge, Christina, Miljanovic, Azra, Ståhlman, Marcus, Klevstig, Martina, Scharin Täng, Margareta, Fogelstrand, Per, Levin, Max, Ekstrand, Matias, Nair, Syam, Redfors, Björn, Omerovic, Elmir, Andersson, Linda, Kimmel, Alan R., Borén, Jan, Levin, Malin C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502866/
https://ncbi.nlm.nih.gov/pubmed/31061399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43335-y
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