Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection

Polyphosphate is an inorganic procoagulant polymer. Here we develop specific inhibitors of polyphosphate and show that this strategy confers thromboprotection in a factor XII-dependent manner. Recombinant Escherichia coli exopolyphosphatase (PPX) specifically degrades polyphosphate, while a PPX vari...

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Publicat a:Nat Commun
Autors principals: Labberton, Linda, Kenne, Ellinor, Long, Andy T., Nickel, Katrin F., Di Gennaro, Antonio, Rigg, Rachel A., Hernandez, James S., Butler, Lynn, Maas, Coen, Stavrou, Evi X., Renné, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025862/
https://ncbi.nlm.nih.gov/pubmed/27596064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12616
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