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Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
Polyphosphate is an inorganic procoagulant polymer. Here we develop specific inhibitors of polyphosphate and show that this strategy confers thromboprotection in a factor XII-dependent manner. Recombinant Escherichia coli exopolyphosphatase (PPX) specifically degrades polyphosphate, while a PPX vari...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025862/ https://ncbi.nlm.nih.gov/pubmed/27596064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12616 |
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