The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduced in plasma in the absence of factor XII or its s...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Nickel, Katrin F., Ronquist, Göran, Langer, Florian, Labberton, Linda, Fuchs, Tobias A., Bokemeyer, Carsten, Sauter, Guido, Graefen, Markus, Mackman, Nigel, Stavrou, Evi X., Ronquist, Gunnar, Renné, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566812/
https://ncbi.nlm.nih.gov/pubmed/26153520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-622811
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