The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities

The plasma protein factor XII (FXII) is the initiating protease of the procoagulant and proinflammatory contact system. FXII activates both the bradykinin (BK) producing kallikrein-kinin system and the intrinsic pathway of coagulation. Contact with negatively charged surfaces induces auto-activation...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Worm, Marie, Köhler, Elodie C., Panda, Rachita, Long, Andy, Butler, Lynn M., Stavrou, Evi X., Nickel, Katrin F., Fuchs, Tobias A., Renné, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2015
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620089/
https://ncbi.nlm.nih.gov/pubmed/26605293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2305-5839.2015.09.07
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