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Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing
We present the bottleneck sequencing system (BotSeqS), a next-generation sequencing method that simultaneously quantifies rare somatic point mutations across the mitochondrial and nuclear genomes. BotSeqS combines molecular barcoding with a simple dilution step immediately before library amplificati...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5024639/ https://ncbi.nlm.nih.gov/pubmed/27528664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607794113 |
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