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Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or conceptual data on this topic. To gain insights into this fundamental issue, we formulated a mathematical model for the evolution of somatic mutatio...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Tomasetti, Cristian, Vogelstein, Bert, Parmigiani, Giovanni
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568331/
https://ncbi.nlm.nih.gov/pubmed/23345422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221068110
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