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Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or conceptual data on this topic. To gain insights into this fundamental issue, we formulated a mathematical model for the evolution of somatic mutatio...
Tallennettuna:
| Päätekijät: | , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568331/ https://ncbi.nlm.nih.gov/pubmed/23345422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221068110 |
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