ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an acti...

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發表在:Nat Commun
Main Authors: Chronopoulos, Antonios, Robinson, Benjamin, Sarper, Muge, Cortes, Ernesto, Auernheimer, Vera, Lachowski, Dariusz, Attwood, Simon, García, Rebeca, Ghassemi, Saba, Fabry, Ben, del Río Hernández, Armando
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023948/
https://ncbi.nlm.nih.gov/pubmed/27600527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12630
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