ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an acti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Chronopoulos, Antonios, Robinson, Benjamin, Sarper, Muge, Cortes, Ernesto, Auernheimer, Vera, Lachowski, Dariusz, Attwood, Simon, García, Rebeca, Ghassemi, Saba, Fabry, Ben, del Río Hernández, Armando
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023948/
https://ncbi.nlm.nih.gov/pubmed/27600527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12630
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