ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an acti...

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Publicado en:Nat Commun
Main Authors: Chronopoulos, Antonios, Robinson, Benjamin, Sarper, Muge, Cortes, Ernesto, Auernheimer, Vera, Lachowski, Dariusz, Attwood, Simon, García, Rebeca, Ghassemi, Saba, Fabry, Ben, del Río Hernández, Armando
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023948/
https://ncbi.nlm.nih.gov/pubmed/27600527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12630
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