ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to favour cancer cell invasion. Here we report that ATRA, an acti...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Chronopoulos, Antonios, Robinson, Benjamin, Sarper, Muge, Cortes, Ernesto, Auernheimer, Vera, Lachowski, Dariusz, Attwood, Simon, García, Rebeca, Ghassemi, Saba, Fabry, Ben, del Río Hernández, Armando
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023948/
https://ncbi.nlm.nih.gov/pubmed/27600527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12630
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