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Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
The ratio of the longer (A β42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer’s disease. The relative levels of the different Aβ species are affected by activity and conformation of the γ-...
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| Pubblicato in: | Mol Med |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Feinstein Institute for Medical Research
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5023509/ https://ncbi.nlm.nih.gov/pubmed/27391800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00127 |
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