MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer

Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the proto-oncogene MDM2, and to influence cancer risk. Recently, a third SNP (SNP55C > T; rs2870820) was also reported to a...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Helwa, Reham, Gansmo, Liv B., Romundstad, Pål, Hveem, Kristian, Vatten, Lars, Ryan, Bríd M., Harris, Curtis C., Lønning, Per E., Knappskog, Stian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022009/
https://ncbi.nlm.nih.gov/pubmed/27624283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33153
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