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MDM4 SNP34091 (rs4245739) and its effect on breast‐, colon‐, lung‐, and prostate cancer risk

The MDM4 protein plays an important part in the negative regulation of the tumor suppressor p53 through its interaction with MDM2. In line with this, MDM4 amplification has been observed in several tumor forms. A polymorphism (rs4245739 A>C; SNP34091) in the MDM4 3′ untranslated region has been r...

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Podrobná bibliografie
Vydáno v:Cancer Med
Hlavní autoři: Gansmo, Liv B., Romundstad, Pål, Birkeland, Einar, Hveem, Kristian, Vatten, Lars, Knappskog, Stian, Lønning, Per Eystein
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123711/
https://ncbi.nlm.nih.gov/pubmed/26471763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.555
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