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Crystal Structure and Activity of Francisella novicida UDP-N-acetylglucosamine Acyltransferase

The first step of lipid A biosynthesis in Escherichia coli (E. coli) is catalyzed by LpxA (EcLpxA), an acyltransferase selective for UDP-N-acetylglucosamine (UDP-GlcNAc) and R-3-hydroxymyristoyl-acyl carrier protein (3-OH-C(14)-ACP), and is an essential step in majority of Gram-negative bacteria. Si...

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Bibliographic Details
Published in:Biochem Biophys Res Commun
Main Authors: Joo, Sang Hoon, Chung, Hak Suk
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021990/
https://ncbi.nlm.nih.gov/pubmed/27545601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.08.098
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