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A new G quadruplex with hairpin loop immediately upstream of the human BCL2 P1 promoter modulates transcription
The abnormal over-expression of the BCL2 gene is associated with many human tumors. We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream of the human BCL2 gene P1 promoter. The P1G4 is shown to be a transcription repressor using a promoter-driven luciferase assay; its inhi...
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| Publié dans: | J Am Chem Soc |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5019542/ https://ncbi.nlm.nih.gov/pubmed/26841249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b08596 |
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