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Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures

Human telomeres can form DNA G-quadruplex (G4), an attractive target for anticancer drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for understanding specific recognition by ligands or proteins. Protoberberines are medicinal natural-products known to stabilize telomeric...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Lin, Clement, Wu, Guanhui, Wang, Kaibo, Onel, Buket, Sakai, Saburo, Shao, Yong, Yang, Danzhou
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192034/
https://ncbi.nlm.nih.gov/pubmed/29888501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201804667
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