Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric (n=69) and adult (n=41) livers was quantified by LC-MS/MS. Transporter protein expression of OCT1, OATP1B3, P-gp and MRP3 was age-dependent. Particularly, significant differences were observed in transporter e...

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Pubblicato in:Clin Pharmacol Ther
Autori principali: Prasad, Bhagwat, Gaedigk, Andrea, Vrana, Marc, Gaedigk, Roger, Leeder, J. Steven, Salphati, Laurent, Chu, Xiaoyan, Xiao, Guangqing, Hop, Cornelis E.C.A., Evers, Raymond, Gan, Lawrence, Unadkat, Jashvant D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017908/
https://ncbi.nlm.nih.gov/pubmed/27301780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.409
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