A Conserved Hydrophobic Core in Gα(i1) Regulates G Protein Activation and Release from Activated Receptor

G protein-coupled receptor-mediated heterotrimeric G protein activation is a major mode of signal transduction in the cell. Previously, we and other groups reported that the α5 helix of Gα(i1), especially the hydrophobic interactions in this region, plays a key role during nucleotide release and G p...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Kaya, Ali I., Lokits, Alyssa D., Gilbert, James A., Iverson, T. M., Meiler, Jens, Hamm, Heidi E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016700/
https://ncbi.nlm.nih.gov/pubmed/27462082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745513
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items