Cellular Redox Systems Impact the Aggregation of Cu,Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis

Protein misfolding is implicated in neurodegenerative diseases such as ALS, where mutations of superoxide dismutase 1 (SOD1) account for about 20% of the inherited mutations. Human SOD1 (hSOD1) contains four cysteines, including Cys(57) and Cys(146), which have been linked to protein stability and f...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Álvarez-Zaldiernas, Cristina, Lu, Jun, Zheng, Yujuan, Yang, Hongqian, Blasi, Juan, Solsona, Carles, Holmgren, Arne
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016121/
https://ncbi.nlm.nih.gov/pubmed/27261461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708230
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