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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses

Although the cellular prion protein (PrP(C)) is concentrated at synapses, the factors that target PrP(C) to synapses are not understood. Here we demonstrate that exogenous PrP(C) was rapidly targeted to synapses in recipient neurons derived from Prnp knock-out((0/0)) mice. The targeting of PrP(C) to...

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Publicado en:J Biol Chem
Main Authors: Bate, Clive, Nolan, William, McHale-Owen, Harriet, Williams, Alun
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016113/
https://ncbi.nlm.nih.gov/pubmed/27325697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731117
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