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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses

Although the cellular prion protein (PrP(C)) is concentrated at synapses, the factors that target PrP(C) to synapses are not understood. Here we demonstrate that exogenous PrP(C) was rapidly targeted to synapses in recipient neurons derived from Prnp knock-out((0/0)) mice. The targeting of PrP(C) to...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Bate, Clive, Nolan, William, McHale-Owen, Harriet, Williams, Alun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016113/
https://ncbi.nlm.nih.gov/pubmed/27325697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731117
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