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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses

Although the cellular prion protein (PrP(C)) is concentrated at synapses, the factors that target PrP(C) to synapses are not understood. Here we demonstrate that exogenous PrP(C) was rapidly targeted to synapses in recipient neurons derived from Prnp knock-out((0/0)) mice. The targeting of PrP(C) to...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Bate, Clive, Nolan, William, McHale-Owen, Harriet, Williams, Alun
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016113/
https://ncbi.nlm.nih.gov/pubmed/27325697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731117
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