A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction

G protein–coupled receptor (GPCR) kinases (GRKs) play a critical role in cardiac function by regulating GPCR activity. GRK2 suppresses GPCR signaling by phosphorylating and desensitizing active GPCRs, and through protein-protein interactions that uncouple GPCRs from their downstream effectors. Sever...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Schumacher, Sarah M., Gao, Erhe, Cohen, Maya, Lieu, Melissa, Chuprun, J. Kurt, Koch, Walter J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015886/
https://ncbi.nlm.nih.gov/pubmed/27016525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aae0549
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