Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner

Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood. Here, we find that expression of IDO by tumor cells results in aggressive tumor growth and resistance to T-cell targeting immunotherapies. We...

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Publicat a:Cell Rep
Autors principals: Holmgaard, Rikke B., Zamarin, Dmitriy, Li, Yanyun, Gasmi, Billel, Munn, David H., Allison, James P., Merghoub, Taha, Wolchok, Jedd D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013825/
https://ncbi.nlm.nih.gov/pubmed/26411680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.077
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