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Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner
Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood. Here, we find that expression of IDO by tumor cells results in aggressive tumor growth and resistance to T-cell-targeting immunotherapies. We...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Elsevier
2015-10-01
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| Seria: | Cell Reports |
| Dostęp online: | http://www.sciencedirect.com/science/article/pii/S2211124715009900 |
| Etykiety: |
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