U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3’ End Formation

Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant, and identify aberrantly process...

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Udgivet i:Mol Cell
Main Authors: Park, Sung Mi, Ou, Jianhong, Chamberlain, Lynn, Simone, Tessa M., Yang, Huan, Virbasius, Ching-Man, Ali, Abdullah M., Zhu, Lihua J., Mukherjee, Siddhartha, Raza, Azra, Green, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012111/
https://ncbi.nlm.nih.gov/pubmed/27184077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.011
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