U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3’ End Formation

Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant, and identify aberrantly process...

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Publicat a:Mol Cell
Autors principals: Park, Sung Mi, Ou, Jianhong, Chamberlain, Lynn, Simone, Tessa M., Yang, Huan, Virbasius, Ching-Man, Ali, Abdullah M., Zhu, Lihua J., Mukherjee, Siddhartha, Raza, Azra, Green, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012111/
https://ncbi.nlm.nih.gov/pubmed/27184077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.011
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