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U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3’ End Formation

Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant, and identify aberrantly process...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell
Hauptverfasser: Park, Sung Mi, Ou, Jianhong, Chamberlain, Lynn, Simone, Tessa M., Yang, Huan, Virbasius, Ching-Man, Ali, Abdullah M., Zhu, Lihua J., Mukherjee, Siddhartha, Raza, Azra, Green, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012111/
https://ncbi.nlm.nih.gov/pubmed/27184077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.011
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