U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3’ End Formation

Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant, and identify aberrantly process...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Cell
Autori principali: Park, Sung Mi, Ou, Jianhong, Chamberlain, Lynn, Simone, Tessa M., Yang, Huan, Virbasius, Ching-Man, Ali, Abdullah M., Zhu, Lihua J., Mukherjee, Siddhartha, Raza, Azra, Green, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012111/
https://ncbi.nlm.nih.gov/pubmed/27184077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.011
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi