Targeting the HER family with Pan-HER effectively overcomes resistance to cetuximab

Cetuximab, an antibody against the Epidermal Growth Factor Receptor (EGFR) has shown efficacy in treating head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer and non-small cell lung cancer (NSCLC). Despite the clinical success of cetuximab, many patients do not respond to cet...

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Pubblicato in:Mol Cancer Ther
Autori principali: Iida, Mari, Bahrar, Harsh, Brand, Toni M, Pearson, Hannah E, Coan, John P, Orbuch, Rachel A, Flanigan, Bailey G, Swick, Adam D, Prabakaran, Prashanth, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Salgia, Ravi, Kimple, Randy J, Wheeler, Deric L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010956/
https://ncbi.nlm.nih.gov/pubmed/27422810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0012
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