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Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase belonging to the HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to down stream activation of the PI3K/AKT, RAS/RAF/MEK/ERK and PLCγ/PKC pathways that influence cell proliferation, surviv...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100630/ https://ncbi.nlm.nih.gov/pubmed/21293176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.9.15050 |
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