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Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase belonging to the HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to down stream activation of the PI3K/AKT, RAS/RAF/MEK/ERK and PLCγ/PKC pathways that influence cell proliferation, surviv...

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Autori principali: Brand, Toni M, Iida, Mari, Wheeler, Deric L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100630/
https://ncbi.nlm.nih.gov/pubmed/21293176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.9.15050
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