Activation of Wnt/beta-catenin in Ewing sarcoma cells antagonizes EWS/ETS function and promotes phenotypic transition to more metastatic cell states

Ewing sarcomas are characterized by the presence of EWS/ETS fusion genes in the absence of other recurrent genetic alterations and mechanisms of tumor heterogeneity that contribute to disease progression remain unclear. Mutations in the Wnt/beta-catenin pathway are rare in Ewing sarcoma but the Wnt...

詳細記述

保存先:
書誌詳細
出版年:Cancer Res
主要な著者: Pedersen, Elisabeth A., Menon, Rajasree, Bailey, Kelly M., Thomas, Dafydd G., Van Noord, Raelene A., Tran, Jenny, Wang, Hongwei, Qu, Ping Ping, Hoering, Antje, Fearon, Eric R., Chugh, Rashmi, Lawlor, Elizabeth R.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010452/
https://ncbi.nlm.nih.gov/pubmed/27364557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3422
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