Wnt/β-catenin–activated Ewing sarcoma cells promote the angiogenic switch

Wnt/β-catenin signaling is active in small subpopulations of Ewing sarcoma cells, and these cells display a more metastatic phenotype, in part due to antagonism of EWS-FLI1–dependent transcriptional activity. Importantly, these β-catenin–activated Ewing sarcoma cells also alter secretion of extracel...

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Udgivet i:JCI Insight
Main Authors: Hawkins, Allegra G., Pedersen, Elisabeth A., Treichel, Sydney, Temprine, Kelsey, Sperring, Colin, Read, Jay A., Magnuson, Brian, Chugh, Rashmi, Lawlor, Elizabeth R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406270/
https://ncbi.nlm.nih.gov/pubmed/32544094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135188
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