Activation of Wnt/beta-catenin in Ewing sarcoma cells antagonizes EWS/ETS function and promotes phenotypic transition to more metastatic cell states

Ewing sarcomas are characterized by the presence of EWS/ETS fusion genes in the absence of other recurrent genetic alterations and mechanisms of tumor heterogeneity that contribute to disease progression remain unclear. Mutations in the Wnt/beta-catenin pathway are rare in Ewing sarcoma but the Wnt...

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Vydáno v:Cancer Res
Hlavní autoři: Pedersen, Elisabeth A., Menon, Rajasree, Bailey, Kelly M., Thomas, Dafydd G., Van Noord, Raelene A., Tran, Jenny, Wang, Hongwei, Qu, Ping Ping, Hoering, Antje, Fearon, Eric R., Chugh, Rashmi, Lawlor, Elizabeth R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010452/
https://ncbi.nlm.nih.gov/pubmed/27364557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3422
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