Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination

Toll-like receptors (TLRs) have critical roles in innate immunity and inflammation and the detailed mechanisms by which TLR signaling is fine tuned remain unclear. Keratin 8 (CK8) belongs to the type II keratin family and is the major compontent of the intermediate filaments of simple or single-laye...

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Publicado no:Sci Rep
Main Authors: Dong, Xiao-Ming, Liu, En-Dong, Meng, Yun-Xiao, Liu, Chao, Bi, Ya-Lan, Wu, Huan-Wen, Jin, Yan-Chao, Yao, Jing-Hui, Tang, Liu-Jun, Wang, Jian, Li, Min, Zhang, Chao, Yu, Miao, Zhan, Yi-Qun, Chen, Hui, Ge, Chang-Hui, Yang, Xiao-Ming, Li, Chang-Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009362/
https://ncbi.nlm.nih.gov/pubmed/27586056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32710
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