Keratin 8 reduces colonic permeability and maintains gut microbiota homeostasis, protecting against colitis and colitis-associated tumorigenesis

Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In the present study, we found that CK8 is downregulated in the...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Liu, Chao, Liu, En-Dong, Meng, Yun-Xiao, Dong, Xiao-Ming, Bi, Ya-Lan, Wu, Huan-Wen, Jin, Yan-Chao, Zhao, Ke, Li, Jian-Jie, Yu, Miao, Zhan, Yi-Qun, Chen, Hui, Ge, Chang-Hui, Yang, Xiao-Ming, Li, Chang-Yan
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722522/
https://ncbi.nlm.nih.gov/pubmed/29228570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18241
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